Publications

  • 1. Stromnes IM, Hulbert A, Rollins MR, Basom RS, Delrow J, Bonson P, Burrack AL, Hingorani SR, Greenberg PD. Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer. J Immunother Cancer. 2022 Feb;10(2):e003525. doi: 10.1136/jitc-2021-003525. PMID: 35210305; PMCID: PMC8883283.
  • 2. Boyer S, Lee HJ, Steele N, Zhang L, Sajjakulnukit P, Andren A, Ward MH, Singh R, Basrur V, Zhang Y, Nesvizhskii AI, Pasca di Magliano M, Halbrook CJ, Lyssiotis CA. Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway. Elife. 2022 Feb 14;11:e73796. doi: 10.7554/eLife.73796. PMID: 35156921; PMCID: PMC8843093.
  • 3. Helms EJ, Berry MW, Chaw RC, DuFort CC, Sun D, Onate MK, Oon C, Bhattacharyya S, Sanford-Crane H, Horton W, Finan JM, Sattler A, Makar R, Dawson DW, Xia Z, Hingorani SR, Sherman MH. Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts. Cancer Discov. 2022 Feb;12(2):484-501. doi: 10.1158/2159-8290.CD-21-0601. Epub 2021 Sep 21. PMID: 34548310; PMCID: PMC8831457.
  • 4. Frankel TL, Pasca di Magliano M. Immune sensing of microbial metabolites: Action at the tumor. Immunity. 2022 Feb 8;55(2):192-194. doi: 10.1016/j.immuni.2022.01.009. PMID: 35139348.
  • 5. Cleary JM, Wolpin BM, Dougan SK, Raghavan S, Singh H, Huffman B, Sethi NS, Nowak JA, Shapiro GI, Aguirre AJ, D'Andrea AD. Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 Dec 15;27(24):6622-6637. doi: 10.1158/1078-0432.CCR-21-1367. Epub 2021 Jul 20. PMID: 34285063; PMCID: PMC8678153.
  • 6. Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 2021 Dec 9;184(25):6119-6137.e26. doi: 10.1016/j.cell.2021.11.017. PMID: 34890551; PMCID: PMC8822455.
  • 7. Stump CT, Roehle K, Manjarrez Orduno N, Dougan SK. Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer. Open Biol. 2021 Nov;11(11):210245. doi: 10.1098/rsob.210245. Epub 2021 Nov 17. PMID: 34784792; PMCID: PMC8595997.
  • 8. Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK. Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids. J Immunother Cancer. 2021 Nov;9(11):e003213. doi: 10.1136/jitc-2021-003213. PMID: 34789550; PMCID: PMC8601084.
  • 9. Singh H, Perez K, Wolpin BM, Aguirre AJ. Beyond the Front Line: Emerging Data for Maintenance Therapy in Pancreatic Cancer. J Clin Oncol. 2021 Oct 10;39(29):3199-3206. doi: 10.1200/JCO.21.01510. Epub 2021 Aug 24. PMID: 34428095; PMCID: PMC8500570.
  • 10. Crawford HC. Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation. Genes Dev. 2021 Oct 1;35(19-20):1325-1326. doi: 10.1101/gad.348971.121. PMID: 34599002; PMCID: PMC8494204.
  • 11. Bravi B, Balachandran VP, Greenbaum BD, Walczak AM, Mora T, Monasson R, Cocco S. Probing T-cell response by sequence-based probabilistic modeling. PLoS Comput Biol. 2021 Sep 2;17(9):e1009297. doi: 10.1371/journal.pcbi.1009297. PMID: 34473697; PMCID: PMC8476001.
  • 12. Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021 Sep 2;184(18):4753-4771.e27. doi: 10.1016/j.cell.2021.07.020. Epub 2021 Aug 12. PMID: 34388391; PMCID: PMC8557351.
  • 13. Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, Zhang Y, Pasca di Magliano M, Crawford HC. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021 Aug 15;81(16):4305-4318. doi: 10.1158/0008-5472.CAN-20-3929. Epub 2021 May 28. PMID: 34049975; PMCID: PMC8445065.
  • 14. Pelissier Vatter FA, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D. Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. J Exp Med. 2021 Aug 2;218(8):e20202579. doi: 10.1084/jem.20202579. Epub 2021 Jun 28. PMID: 34180950; PMCID: PMC8241538.
  • 15. Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, Li J, Ilic N, Hwang J, Hong AL, Giacomelli AO, Gjoerup O, Root DE, Hahn WC. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Rep. 2021 Jul 27;36(4):109443. doi: 10.1016/j.celrep.2021.109443. PMID: 34320363; PMCID: PMC8350598.
  • 16. Stone ML, Lee J, Herrera VM, Graham K, Lee JW, Huffman A, Coho H, Tooker E, Myers MI, Giannone M, Li Y, Buckingham TH, Long KB, Beatty GL. TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy. JCI Insight. 2021 Jul 22;6(14):e146314. doi: 10.1172/jci.insight.146314. PMID: 34101617; PMCID: PMC8410039.
  • 17. Beatty GL, Werba G, Lyssiotis CA, Simeone DM. The biological underpinnings of therapeutic resistance in pancreatic cancer. Genes Dev. 2021 Jul 1;35(13-14):940-962. doi: 10.1101/gad.348523.121. Epub 2021 Jun 11. PMID: 34117095; PMCID: PMC8247606.
  • 18. Rojas LA, Balachandran VP. Scaling the immune incline in PDAC. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):453-454. doi: 10.1038/s41575-021-00475-9. PMID: 34083798; PMCID: PMC8173858.
  • 19. Ling Huang, Ridhdhi Desai, Daniel N Conrad, Nayara C Leite, Dipikaa Akshinthala, Christine Maria Lim, Raul Gonzalez, Lakshmi B Muthuswamy, Zev Gartner, Senthil K Muthuswamy. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021 Jun 3;28(6):1090-1104.e6. doi: 10.1016/j.stem.2021.03.022. Epub 2021 Apr 28. PMID: 33915081. PMCID: PMC8202734
  • 20. S Dhara, S Chhangawala, H Chintalapudi, G Askan, V Aveson, A L Massa, L Zhang, D Torres, A P Makohon-Moore, N Lecomte, J P Melchor, J Bermeo, A Cardenas, S Sinha, D Glassman, R Nicolle, R Moffitt, K H Yu, S Leppanen, S Laderman, B Curry, J Gui, V P Balachandran, C Iacobuzio-Donahue, R Chandwani, C S Leslie, S D Leach. Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility. Nat Commun. 2021 May 24;12(1):3044. doi: 10.1038/s41467-021-23237-2. PMID: 34031415.PMCID: PMC8144607
  • 21. 63. Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 May 19;13(594):eabf5058. PMID: 34011631 DOI: 10.1126/scitranslmed.abf5058
  • 22. Jimmy A Guo, Hannah I Hoffman, Stuti G Shroff, Peter Chen, Peter G Hwang, Daniel Y Kim, Daniel W Kim, Stephanie W Cheng, Daniel Zhao, Brandon A Mahal, Mohammed Alshalalfa, Andrzej Niemierko, Jennifer Y Wo, Jay S Loeffler, Carlos Fernandez-Del Castillo, Tyler Jacks, Andrew J Aguirre, Theodore S Hong, Mari Mino-Kenudson, William L Hwang. Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. Clin Cancer Res. 2021 May 15;27(10):2807-2815. doi: 10.1158/1078-0432.CCR-20-4382. Epub 2021 Feb 25. PMID: 33632928. PMCID: PMC8127360
  • 23. Nina G Steele, Giulia Biffi, Samantha B Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Hansma, Carlos Espinoza, Ahmed Abbas, Stephanie The, Valerie Irizarry-Negron, Christopher J Halbrook, Nicole E Franks, Megan T Hoffman, Kristee Brown, Eileen S Carpenter, Zeribe C Nwosu, Craig Johnson, Fatima Lima, Michelle A Anderson, Youngkyu Park, Howard C Crawford, Costas A Lyssiotis, Timothy L Frankel, Arvind Rao, Filip Bednar, Andrzej A Dlugosz, Jonathan B Preall, David A Tuveson, Benjamin L Allen, Marina Pasca di Magliano. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021 Apr 1;27(7):2023-2037. doi: 10.1158/1078-0432.CCR-20-3715. Epub 2021 Jan 25. PMID: 33495315. PMCID: PMC8026631
  • 24. Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, Alexander A Girgis, Valerie Gunchick, Yaqing Zhang, Costas A Lyssiotis, Timothy L Frankel, Filip Bednar, Arvind Rao, Vaibhav Sahai , Lonnie D Shea, Howard C Crawford, Marina Pasca di Magliano. Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages. Life Sci Alliance. 2021 Mar 29;4(6):e202000935. doi: 10.26508/lsa.202000935. Print 2021 Jun. PMID: 33782087. PMCID: PMC8091600
  • 25. Jason J Kwon, William C Hahn. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Mol Cell Biol. 2021 Mar 24;41(4):e00627-20. doi: 10.1128/MCB.00627-20. Print 2021 Mar 24. PMID: 33526449. PMCID: PMC8088128
  • 26. Sara A Vayrynen, Jinming Zhang, Chen Yuan, Juha P Vayryne, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C Linehan, Andrew J Aguirre, Charles S Fuchs, Lisa M Coussens, Daniel T Chang, Albert C Koong, Aram F Hezel, Shuji Ogino, Jonathan A Nowak, Brian M Wolpin. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2021 Feb 15;27(4):1069-1081. doi: 10.1158/1078-0432.CCR-20-3141. Epub 2020 Dec 1. PMID: 33262135
  • 27. Grace G Bushnell, Sophia M Orbach, Jeffrey A Ma, Howard C Crawford, Max S Wicha, Jacqueline S Jeruss, Lonnie D Shea. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021 Feb;269:120632. doi: 10.1016/j.biomaterials.2020.120632. Epub 2020 Dec 23. PMID: 33418200. PMCID: PMC7870556
  • 28. Douglas E Biancur, Kevin S Kapner, Keisuke Yamamoto, Robert S Banh, Jasper E Neggers, Albert S W Sohn, Warren Wu, Robert T Manguso, Adam Brown, David E Root, Andrew J Aguirre, Alec C Kimmelman. Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer. Cell Metab. 2021 Jan 5;33(1):199-210.e8. doi: 10.1016/j.cmet.2020.10.018. Epub 2020 Nov 4. PMID: 33152323. PMCID: PMC7790858
  • 29. Genevieve M Gerhard, Ruben Bill, Marius Messemaker, Allon M Klein, Mikael J Pittet. Tumor-infiltrating dendritic cell states are conserved across solid human cancers. J Exp Med. 2021 Jan 4;218(1):e20200264. doi: 10.1084/jem.20200264. PMID: 33601412. PMCID: PMC7754678
  • 30. Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume Kugener, Jeremie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y Li, Liam F Spurr, Westley W Wu, Adam D Durbin, Brian M Wolpin, Federica Piccioni, David E Root, Jesse S Boehm, Andrew D Cherniack, Aviad Tsherniak, Andrew L Hong, William C Hahn, Kimberly Stegmaier, Todd R Golub, Francisca Vazquez, Andrew J Aguirre. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020 Dec 15;33(11):108493. doi: 10.1016/j.celrep.2020.108493. PMID: 33326793
  • 31. Ivy X Chen, Kathleen Newcomer, Kristen E Pauken, Vikram R Juneja, Kamila Naxerova, Michelle W Wu, Matthias Pinter, Debattama R Sen, Meromit Singe, Arlene H Sharpe, Rakesh K Jain. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23684-23694. doi: 10.1073/pnas.2002806117. Epub 2020 Sep 9. PMID: 32907939. PMCID: PMC7519254
  • 32. Max M Wattenberg, Gregory L Beatty. Overcoming immunotherapeutic resistance by targeting the cancer inflammation cycle. Semin Cancer Biol. 2020 Oct;65:38-50. doi: 10.1016/j.semcancer.2020.01.002. Epub 2020 Jan 15. PMID: 31954172. PMCID: PMC7363515
  • 33. Holly Brunton, Ian M Garner, Ulla-Maja Bailey, Rosie Upstill-Goddard, Peter J Bailey. Using Chromatin Accessibility to Delineate Therapeutic Subtypes in Pancreatic Cancer Patient-Derived Cell Lines. STAR Protoc. 2020 Aug 4;1(2):100079. doi: 10.1016/j.xpro.2020.100079. eCollection 2020 Sep 18. PMID: 33111113.PMCID: PMC7580199
  • 34. Sammy Ferri-Borgogno, Sugata Barui, Amberly M McGee, Tamara Griffiths, Pankaj K Singh, Cortt G Piett, Bidyut Ghosh, Sanchari Bhattacharyya, Aatur Singhi, Kith Pradhan 4, Amit Verma, Zac Nagel, Anirban Maitra, Sonal Gupta. Paradoxical Role of AT-rich Interactive Domain 1A in Restraining Pancreatic Carcinogenesis. Cancers (Basel). 2020 Sep 21;12(9):2695. doi: 10.3390/cancers12092695. PMID: 32967217. PMCID: PMC7564752
  • 35. McFarland, James M; Paolella, Brenton R; Warren, Allison; Geiger-Schuller, Kathryn; Shibue, Tsukasa; Rothberg, Michael; Kuksenko, Olena; Colgan, William N; Jones, Andrew; Chambers, Emily; Dionne, Danielle; Bender, Samantha; Wolpin, Brian M; Ghandi, Mahmoud; Tirosh, Itay; Rozenblatt-Rosen, Orit; Roth, Jennifer A; Golub, Todd R; Regev, Aviv; Aguirre, Andrew J; Vazquez, Francisca; Tsherniak, Aviad. Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nat Commun. 2020 Aug 27;11(1):4296. doi: 10.1038/s41467-020-17440-w. PMID: 32855387. PMCID: PMC7453022
  • 36. Hoshino, Ayuko; Kim, Han Sang; Bojmar, Linda; Gyan, Kofi Ennu; Cioffi, Michele; Hernandez, Jonathan; Zambirinis, Constantinos P; Rodrigues, Gonzalo; Molina, Henrik; Heissel, Soren; Mark, Milica Tesic; Steiner, Loic; Benito-Martin, Alberto; Lucotti, Serena; Di Giannatale, Angela; Offer, Katharine; Nakajima, Miho; Williams, Caitlin; Nogues, Laura; Pelissier Vatter, Fanny A; Hashimoto, Ayako; Davies, Alexander E; Freitas, Daniela; Kenific, Candia M; Ararso, Yonathan; Buehring, Weston; Lauritzen, Pernille; Ogitani, Yusuke; Sugiura, Kei; Takahashi, Naoko; Ale?kovi?, Ma?a; Bailey, Kayleen A; Jolissant, Joshua S; Wang, Huajuan; Harris, Ashton; Schaeffer, L Miles; Garcia-Santos, Guillermo; Posner, Zoe; Balachandran, Vinod P; Khakoo, Yasmin; Raju, G Praveen; Scherz, Avigdor; Sagi, Irit; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Malladi, Mahathi; Petriccione, Mary; De Braganca, Kevin C; Donzelli, Maria; Fischer, Cheryl; Vitolano, Stephanie; Wright, Geraldine P; Ganshaw, Lee; Marrano, Mariel; Ahmed, Amina; DeStefano, Joe; Danzer, Enrico; Roehrl, Michael H A; Lacayo, Norman J; Vincent, Theresa C; Weiser, Martin R; Brady, Mary S; Meyers, Paul A; Wexler, Leonard H; Ambati, Srikanth R; Chou, Alexander J; Slotkin, Emily K; Modak, Shakeel; Roberts, Stephen S; Basu, Ellen M; Diolaiti, Daniel; Krantz, Benjamin A; Cardoso, Fatima; Simpson, Amber L; Berger, Michael; Rudin, Charles M; Simeone, Diane M; Jain, Maneesh; Ghajar, Cyrus M; Batra, Surinder K; Stanger, Ben Z; Bui, Jack; Brown, Kristy A; Rajasekhar, Vinagolu K; Healey, John H; de Sousa, Maria; Kramer, Kim; Sheth, Sujit; Baisch, Jeanine; Pascual, Virginia; Heaton, Todd E; La Quaglia, Michael P; Pisapia, David J; Schwartz, Robert; Zhang, Haiying; Liu, Yuan; Shukla, Arti; Blavier, Laurence; DeClerck, Yves A; LaBarge, Mark; Bissell, Mina J; Caffrey, Thomas C; Grandgenett, Paul M; Hollingsworth, Michael A; Bromberg, Jacqueline; Costa-Silva, Bruno; Peinado, Hector; Kang, Yibin; Garcia, Benjamin A; O'Reilly, Eileen M; Kelsen, David; Trippett, Tanya M; Jones, David R; Matei, Irina R; Jarnagin, William R; Lyden, David. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Aug 20;182(4):1044-1061.e18. doi: 10.1016/j.cell.2020.07.009. Epub 2020 Aug 13. PMID: 32795414. PMCID: PMC7522766
  • 37. John D Martin, Dan G Duda, Rakesh K Jain. Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer?. Circ Res. 2020 Aug 28;127(6):724-726. doi: 10.1161/CIRCRESAHA.120.317720. Epub 2020 Aug 27. PMID: 32853096. PMCID: PMC7462096
  • 38. Jeanine M Ruggeri, Janusz Franco-Barraza, Anjum Sohail, Yaqing Zhang, Daniel Long, Marina Pasca di Magliano, Edna Cukierman, Rafael Fridman, Howard C Crawford. Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma. Am J Pathol. 2020 Aug;190(8):1735-1751. doi: 10.1016/j.ajpath.2020.03.020. Epub 2020 Apr 24. PMID: 32339496. PMCID: PMC7416078
  • 39. Abdel N. Hosein, Rolf A. Brekken & Anirban Maitra. Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol. 2020 Aug;17(8):487-505. doi: 10.1038/s41575-020-0300-1. Epub 2020 May 11. PMID: 32393771. PMCID: PMC8284850
  • 40. Arthur Brannon III, Donovan Drouillard, Nina Steele, Shadae Schoettle, Ethan V. Abel, Howard C. Crawford & Marina Pasca di Magliano. Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition. Sci Rep. 2020 Jul 7;10(1):11133. doi: 10.1038/s41598-020-67814-9. PMID: 32636409. PMCID: PMC7340786
  • 41. Storz, Peter; Crawford, Howard C. Carcinogenesis of Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2020 Jun;158(8):2072-2081. PMID: 32199881 PMCID: PMC7282937 DOI: 10.1053/j.gastro.2020.02.059
  • 42. Ferguson, Fleur M; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L; Kuljanin, Miljan; Kalekar, Radha L; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W S; Sulahian, Rita; Li, Lianbo; Poulin, Emily J; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R; Vasta, James D; Ohi, Ryoma; Sim, Taebo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M; Robers, Matthew B; Muthaswamy, Senthil; Lin, Charles Y; Look, A Thomas; Haigis, Kevin M; Mancias, Joseph D; Wolpin, Brian M; Aguirre, Andrew J; Hahn, William C; Westover, Kenneth D; Gray, Nathanael S. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Jun;16(6):635-643. PMID: 32251410 PMCID: PMC7246176 DOI: 10.1038/s41589-020-0506-0
  • 43. Weissleder, Ralph; Pittet, Mikael J. The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020 May;4(5):489-498. PMID: 32203281 DOI: 10.1038/s41551-020-0524-y
  • 44. Chang, Renee B; Beatty, Gregory L. The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance. J Leukoc Biol. 2020 Apr 9. PMID: 32272502 DOI: 10.1002/JLB.3MIR0320-475R
  • 45. Martin, John D; Cabral, Horacio; Stylianopoulos, Triantafyllos; Jain, Rakesh K. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nat Rev Clin Oncol. 2020 Apr;17(4):251-266. PMID: 32034288 DOI: 10.1038/s41571-019-0308-z
  • 46. Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG. Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma. Hepatology. 2020 Apr;71(4):1247-1261. doi: 10.1002/hep.30889. Epub 2019 Oct 14. PMID: 31378984. PMCID: PMC7000304
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