One of the most promising approaches in cancer treatment in the past decade is immunotherapy- stimulating the patient's immune system to treat cancer. Due to the uniquely immunosuppressive microenvironment of pancreatic ductal adenocarcinoma (PDA), immunotherapeutic approaches have given disappointing results. The proposed collaborative research proposal uses multiple unique in vivo and in vitro preclinical models to define methods to disrupt the multicellular crosstalk that establishes the immunosuppressive microenvironment of PDA, thereby enhancing immunotherapeutic responses for PDA treatment. For more information click here