Pancreatic cancer is a deadly disease with few effective treatment options and a dismal overall prognosis. While immune based therapies have not shown success to date in pancreatic cancer patients, improved immunotherapy strategies could have a profound impact on patient outcomes. In this project, we will utilize state-of-the-art technologies in patient-derived specimens and faithful mouse models to comprehensively define the key elements of the pancreatic cancer microenvironment to identify and test novel strategies that may alter the microenvironment for therapeutic gain. For more information click here